Purine Metabolism in Normal and Thioguanine-Resistant Neuroblastoma
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چکیده
منابع مشابه
Purine metabolism in normal and thioguanine-resistant neuroblastoma.
Purine metabolism has been examined in a clonal line of mouse neuroblastoma cells resistant to the cytotoxic effects of 6-thioguanine. Comparative studies in the resistant and parental lines indicate that the former cells have less than 1% of normal hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) activity. The activities of other enzymes important in the de novo and salvage pathways of puri...
متن کاملThe Metabolism of Thioguanine in Purine Analog-resistant Cells.
thioguanine is attributable to incorporation of the anti metabolite into deoxyribonucleic acid (DNA) and that re sistance may be the result of a lower capacity for such in corporation; and (d) Paterson (17, 19), using a 6-mercap topurine-resistant Ehrlich carcinoma, proposed a decreased rate of transport of drug across the cell membrane as a possible mechanism for the resistant character of thi...
متن کاملFeedback-Resistant Phosphoribosylpyrophosphate Synthetase Associated with Purine Overproduction and Gout PHOSPHORIBOSYLPYROPHOSPHATE AND PURINE METABOLISM
other family members investigated. The fibroblast studA preliminary report was presented at the Annual Meeting of the Israeli Association of Chemical Pathology, Rehovot, Israel, March 1974. Professor de Vries is an Established Investigator of the Chief Scientist's Bureau, Ministry of Health. Received for publication 6 February 1975 and in revised form 7 July 1975. ies demonstrate the following ...
متن کاملFeedback-Resistant Phosphoribosylpyrophosphate Synthetase Associated with Purine Overproduction and Gout PHOSPHORIBOSYLPYROPHOSPHATE AND PURINE METABOLISM
other family members investigated. The fibroblast studA preliminary report was presented at the Annual Meeting of the Israeli Association of Chemical Pathology, Rehovot, Israel, March 1974. Professor de Vries is an Established Investigator of the Chief Scientist's Bureau, Ministry of Health. Received for publication 6 February 1975 and in revised form 7 July 1975. ies demonstrate the following ...
متن کاملThe metabolism of 9-butyl-6-thioguanine in normal and neoplastic tissues.
The metabolism of 9-butyl thioguanine (9-BTG)1 was studied in normal tissues and the Ehrlich ascites tumor with and without pretreatment with azaserine. The study of the distribution and metabolism of the drug was facilitated by the synthesis of 9-butyl-6-thioguanine-8-C14. The results showed that 9-BTG was rapidly cleared from the blood, rapidly catabolized, and that the metabolites were rapid...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1973
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.70.12.3880